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They learned to go straight to the top and contact him (or his predecessors) directly, as Laurie Girand did Patients official roles in the drug approval process grew over the years as well At least one patient or consumer representative must be appointed to each advisory committee In a sign of the times, Matt Sharp the AIDS activist and dancer from Oklahoma who protested at the big demonstration at FDA headquarters in 1988 was appointed to the Antiviral Drugs Advisory Committee in April 2003 He now praises the FDA members knowledge and competence.

SRM operations for unmanaged disk areas are handled directly by JSRM This allows JSRM to be deployed at a site that has only user-managed disk space (no disk management system, no tertiary storage system) JSRM can also be layered above an existing storage manager Certain operations on the managed disk areas and silo are then performed by deferring the requests to a separate object or SRM, which in itself can be a Web service or a Java class As long as every site uses the same SRM or Java interface, JSRM can be deployed as a gateway, adding functionality without modifying the secondary SRM s code The Java API for XML Messaging (JAXM) is used to build, send, receive, and decompose the SOAP messages in this work The current version of JAXM implements SOAP 11 with Attachments messaging.

This results in the following being written to the Output panel:

There is also a patient consultant program, in which the FDA selects and trains patient representatives who will provide advice to the FDA and to the drug sponsor on topics such as clinical trial design, endpoint determination, expanded access protocol development, and clinical trial patient recruitment strategies earlier in the application process, according to the FDA s official description The idea is to add the patient s point of view to all the other considerations of dosage, safety, effectiveness, and scientific validity Often, this means reminding the scientists and bureaucrats that live human beings are being tested, and tests can hurt For instance, Mike Katz of the International Myeloma Foundation sat in on a meeting in the late 1990s where some regulators and drug company researchers were discussing how to conduct bone marrow biopsies, in order to check patients responses to a cancer medication.

It takes care of all low-level XML communications JSRM servers focus only on providing the service the user has requested 3424 Reliable le transfer The next essential component for a data Grid is a service to move datasets from one Grid node (site) to another, otherwise known as third party le transfers This service must be reliable, gracefully handling intermittent network or node unavailability problems A reliable le transfer service could be included in the site JSRM service (additional methods of the same Web service) However, in this project, we decided to implement it as an independent Java server class with a Web service interface In this way, Reliable File Transfer functionality can be easily invoked by JSRM or serve as a user callable Web service.

Another approach to finding feeds is to take all those buttons and links to feeds embedded in a Web page and turn them into metadata in an easily located spot in HTML. The conventional place to do that is in the <head> tag in an HTML document, where Web page authors already place things such as the page title, keywords, descriptions, and other resources (such as pointers to associated CSS files and JavaScript sources). For example, a Web page might start off with a preamble like this: